Purine Phosphoribosyltransferases
نویسندگان
چکیده
منابع مشابه
Purine phosphoribosyltransferases of Salmonella typhimurium.
Evidence is presented that Salmonella typhimurium contains two guanine phosphoribosyltransferases.
متن کاملArtemia purine phosphoribosyltransferases. Purification and characterization.
Adenine phosphoribosyltransferase (APRTase) and hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) have been purified from Artemia cysts and nauplii to apparent homogeneity, as determined by SDS-PAGE. The purification includes affinity chromatography on AMP-Sepharose, which binds both enzymes, and they are eluted at different 5-phospho-alpha-D-ribosyl diphosphate (PP-Rib-P) concentration...
متن کاملThe substrate specificity of purine phosphoribosyltransferases in Schizosaccharomyces pombe.
1. The activities of the purine phosphoribosyltransferases (EC 2.4.2.7 and 2.4.2.8) in purine-analogue-resistant mutants of Schizosaccharomyces pombe were checked. An 8-azathioxanthine-resistant mutant lacked hypoxanthine phosphoribosyltransferase, xanthine phosphoribosyltransferase and guanine phosphoribosyltransferase activities (EC 2.4.2.8) and appeared to carry a single mutation. Two 2,6-di...
متن کاملDevelopmental changes in purine phosphoribosyltransferases in human and rat tissues.
1. The hypoxanthine/guanine and adenine phosphoribosyltransferase activities in a wide variety of human tissues were studied during their growth and development from foetal life onward. A wide range of activities develop after birth, with especially high values in the central nervous system and testes. 2. Postnatal development of hypoxanthine/guanine phosphoribosyltransferase was also defined i...
متن کاملLeukocyte purine phosphoribosyltransferases in human leukemias sensitive and resistant to 6-thiopurines.
The levels of leukocyte adenine phosphoribosyltransferase and of hypoxanthine-guanine phosphoribosyltransferase (H-GPRT) were compared in normal control subjects, patients with acute leukemia in remission, and patients with acute leukemia in exacerbation. Significant (p < 0.025) elevations of both the adenine phosphoribsosyltransferase and H-GPRT activities occurred in individuals with leukemia...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.r000002200